Fluralaner Impurity 22 CAS CATO-C4X-218022
| CAS No. | CATO-C4X-218022 |
| Molecular Formula | C18H12Cl2F3NO3 |
| Molecular Weight | 418.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Fluralaner Impurity 22 (CAS CATO-C4X-218022, C18H12Cl2F3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Fluralaner Impurity 22 (C18H12Cl2F3NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12Cl2F3NO3 |
| Molecular Weight | 418.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Fluralaner Standards
- Fluralaner Impurity 21 (CAS CATO-C4X-218021)
- Fluralaner Impurity 6 (CAS 864725-62-2)
- Fluralaner Impurity N1 (CAS 1095275-07-2)
- Fluralaner Impurity N2 (CAS 1095275-26-5)
- Fluralaner impurity 29 (CAS CATO-C4X-218029)
- Fluralaner impurity 37 (CAS CATO-C4X-218037)
- Fluralaner impurity 32 (CAS CATO-C4X-218032)
- Fluralaner Impurity 23 (CAS CATO-C4X-218023)
Recommended Standards
- 5,5'-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2'-bithiophene (CAS 239075-02-6)
- 1161975-56-9 7-(Tributylstannyl)isoquinoline 9722AC C21H33NSn (CAS 1161975-56-9)
- 1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 956754-06-6)
- 5-(Tributylstannyl)isoquinoline (CAS 1161976-13-1)
- Phenacetin Impurity 10 (CAS 15596-57-3)
- Posaconazole Impurity 42 (CAS 357189-96-9)
- 【货号停用，见C4X-127024】Cefaclor Impurity 18 (CAS CATO-C4X-127018)
- 4-Fluoro-2-(methylsulfonyl)nitrobenzene 4925-61-5 TC-307685 (CAS 4925-61-5)
- 2-{3-cyclopropyl-5-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl}acetic acid (CAS 937605-70-4)
- Hexacosyl tetracosanoate (CAS 121878-03-3)
- Propane-1,3-disulfonamide (CAS 13427-51-5)
- Diatrizoic Acid (CAS 117-96-4)
- 2-(1-(4-Methoxyphenyl)-3-oxo-3-phenylpropyl)malononitrile (CAS 77609-08-6)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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