Berberine Impurity 4 CAS CATO-C4X-21994
| CAS No. | CATO-C4X-21994 |
| Molecular Formula | C19H16NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Berberine Impurity 4 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Berberine Impurity 4 (CAS CATO-C4X-21994, C19H16NO4Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Berberine Impurity 4 (C19H16NO4Br) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 402.24 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Berberine Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H16NO4 Br |
| Molecular Weight | 402.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 15 Chloride (CAS 1186107-72-1)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Berberine Impurity 29 (CAS 2375597-30-9)
Recommended Standards
- Atrasentan Impurity 78 (CAS 1058551-22-6)
- Montelukast Impurity N2 (CAS 162515-66-4)
- Vinorelbine Impurity 16 (CAS CATO-C4X-264216)
- 5-Chloro-4-hydrazinyl-8-methylquinoline hydrochloride (CAS 1172239-34-7)
- 5-Methyl-2,3-dihydrobenzofuran-4-ol (CAS 600176-61-2)
- 2-Bromo-6-chloro-1,8-naphthyridine (CAS 1176470-56-6)
- 6-Fluoro-2-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)nitrobenzene (CAS 1774894-18-6)
- N-Ethyl-9-(2-fluorobenzyl)-9H-purin-6-amine (CAS 101154-88-5)
- 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aminehydrochloride (CAS 3880-78-2)
- (Des-Bromo)-Neuropeptide B (1-23) (human) (CAS 434897-64-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com