Phytomenadione/Vitamin K1 Impurity 82 CAS CATO-C4X-220782
| CAS No. | CATO-C4X-220782 |
| Molecular Formula | C12H8O3 |
| Molecular Weight | 200.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Phytomenadione/Vitamin K1 Impurity 82 (CAS CATO-C4X-220782, C12H8O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Phytomenadione/Vitamin K1 Impurity 82 (C12H8O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8O3 |
| Molecular Weight | 200.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Phytomenadione Standards
- Phytomenadione/Vitamin K1 Impurity 124 (CAS CATO-C4X-2207124)
- Phytomenadione/Vitamin K1 Impurity 81 (CAS CATO-C4X-220781)
- Phytomenadione/Vitamin K1 Impurity 88 (CAS CATO-C4X-220788)
- Phytomenadione/Vitamin K1 Impurity 79 (CAS CATO-C4X-220779)
- Phytomenadione/Vitamin K1 Impurity 122 (CAS 571-63-1)
- Phytomenadione/Vitamin K1 Impurity 125 (CAS 49802-39-3)
- Phytomenadione/Vitamin K1 Impurity 80 (CAS CATO-C4X-220780)
- Phytomenadione/Vitamin K1 Impurity 115 (CAS CATO-C4X-2207115)
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