Aprocitentan impurity 1 CAS CATO-C4X-33551
| CAS No. | CATO-C4X-33551 |
| Molecular Formula | C8H12N2O4 |
| Molecular Weight | 200.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Aprocitentan impurity 1 (CAS CATO-C4X-33551), a pharmacopoeial impurity reference standard (molecular formula C8H12N2O4, MW 200.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C8H12N2O4, Aprocitentan impurity 1 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 200.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprocitentan impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O4 |
| Molecular Weight | 200.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Aprocitentan Standards
- Aprocitentan Impurity 9 (CAS CATO-C4X-33559)
- Aprocitentan Impurity 6 (CAS CATO-C4X-33556)
- Aprocitentan Impurity 7 (CAS CATO-C4X-33557)
- Aprocitentan Impurity 8 (CAS CATO-C4X-33558)
- Aprocitentan impurity 2 (CAS CATO-C4X-33552)
- Aprocitentan-d4 (CAS CATO-C4X-335510)
- Aprocitentan Impurity 4 (CAS CATO-C4X-33554)
- Aprocitentan Impurity 5 (CAS CATO-C4X-33555)
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- (E)-4-Bromo-2-(((2-hydroxyphenyl)imino)methyl)-6-methoxyphenol (CAS 1912457-33-0)
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