Roxadustat Impurity 127 CAS CATO-C4X-2213127
| CAS No. | CATO-C4X-2213127 |
| Molecular Formula | C20H24N2O5 |
| Molecular Weight | 372.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Roxadustat Impurity 127 (CAS CATO-C4X-2213127) is a certified pharmaceutical impurity reference standard with the molecular formula C20H24N2O5 and a molecular weight of 372.41 g/mol.
Roxadustat Impurity 127 (C20H24N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H24N2O5 |
| Molecular Weight | 372.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Glycine (CAS 808116-60-1)
- Roxadustat Impurity 139 (CAS CATO-C4X-2213139)
- Roxadustat Impurity 132 (CAS CATO-C4X-2213132)
- Roxadustat Impurity 154 (CAS CATO-C4X-2213154)
- Roxadustat Impurity 34 (CAS CATO-C4X-221334)
- Roxadustat Impurity 38 (CAS CATO-C4X-221338)
- Roxadustat impurity 134 (CAS 2243807-81-8)
- Roxadustat Impurity N5 (CAS 1509958-20-6)
Recommended Standards
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- Upadacitinib Impurity 145 (CAS CATO-C4X-2405145)
- Sildenafil Impurity 77 (CAS CATO-C4X-112877)
- Losartan Potassium EP Impurity E (CAS 120568-11-8)
- Polymyxin Impurity 25 (CAS CATO-C4X-225525)
- 5'-Chloro-2'-hydroxy-3'-nitroacetophenone (CAS 84942-40-5)
- 4-(2-Cyclohexylethoxy)-3-methylaniline (CAS 946663-40-7)
- (1-Methyl-6-indolyl)methanol (CAS 199590-00-6)
- Tert-butyl (5-oxospiro[3.5]Nonan-2-yl)carbamate (CAS 2306260-81-9)
- Ciclesonide Impurity 3 (CAS 204444-44-0)
- Milrinone Impurity 33 (CAS CATO-C4X-109133)
- β-Asp9-Tirzepatide (CAS CATO-CPTD788931)
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