Roxadustat Impurity 143 CAS CATO-C4X-2213143
| CAS No. | CATO-C4X-2213143 |
| Molecular Formula | C20H16O4 |
| Molecular Weight | 320.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Roxadustat Impurity 143 (CAS CATO-C4X-2213143, C20H16O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Roxadustat Impurity 143 (C20H16O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H16O4 |
| Molecular Weight | 320.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Roxadustat Standards
- Roxadustat Impurity 162 (CAS CATO-C4X-2213162)
- Roxadustat Impurity 65 (CAS CATO-C4X-221365)
- Roxadustat Impurity 22 (CAS CATO-C4X-221322)
- Roxadustat Impurity 8 (CAS CATO-C4X-22138)
- Roxadustat impurity 111 (CAS CATO-C4X-2213111)
- Roxadustat Impurity 90 (CAS CATO-C4X-221390)
- Roxadustat Impurity 9 (CAS 2244489-54-9)
- Roxadustat Impurity 57 (CAS 38791-58-1)
Recommended Standards
- Mycophenolate EP Impurity B (CAS 2767988-82-7)
- Pyridoxine Impurity 5 (CAS CATO-C4X-31085)
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- Mycophenolic acid (CAS 24280-93-1)
- Dronedarone Impurity 42 (CAS 113385-32-3)
- Imatinib Impurity 46 (CAS 1170909-72-4)
- Sugammadex Impurity 83 (CAS 2412952-90-8)
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