Roxadustat Impurity 8 CAS CATO-C4X-22138
| CAS No. | CATO-C4X-22138 |
| Molecular Formula | C18H21NO4 |
| Molecular Weight | 315.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Roxadustat Impurity 8 (CAS CATO-C4X-22138), a pharmacopoeial impurity reference standard (molecular formula C18H21NO4, MW 315.36 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H21NO4, Roxadustat Impurity 8 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 315.36 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H21NO4 |
| Molecular Weight | 315.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 22 (CAS CATO-C4X-221322)
- Roxadustat Impurity 57 (CAS 38791-58-1)
- Roxadustat Impurity 86 (CAS CATO-C4X-221386)
- Roxadustat Impurity 89 (CAS CATO-C4X-221389)
- Roxadustat Impurity 92 (CAS CATO-C4X-221392)
- Roxadustat Impurity N6 (CAS 1421312-32-4)
- Roxadustat Impurity 165 (CAS CATO-C4X-2213165)
- Roxadustat Impurity 143 (CAS CATO-C4X-2213143)
Recommended Standards
- Fenoterol Impurity 4 (CAS 161040-25-1)
- Felbinac Trometamol Impurity 2 (CAS CATO-C4X-33682)
- Oxycodone (CAS 76-42-6)
- (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one (CAS 240131-71-9)
- Lotilaner Impurity 19 (CAS CATO-C4X-325619)
- Sulindac EP Impurity C-d3 (CAS 250608-66-3)
- Ticagrelor impurity 104 (CAS CATO-C4X-1093104)
- 4-(1-Methyl-1H-pyrazol-3-yl)piperidine dihydrochloride (CAS 1956356-29-8)
- 2-{[(3,4-dichlorophenyl)methyl]sulfanyl}-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole (CAS 339277-06-4)
- 2-((1,3-Dimethyl-1H-pyrazol-4-yl)methylene)malononitrile (CAS 514220-43-0)
- 6-Bromo-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole 2,2-dioxide (CAS 1488260-07-6)
- 5-(3-Chloro-2-methylphenyl)-5-oxopentanoic acid (CAS 1417462-41-9)
- N,N,4-Trimethyl-5-(1-tosylpyrrolidin-2-yl)pyridin-2-amine (CAS 1352537-67-7)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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