Roxadustat Impurity 162 CAS CATO-C4X-2213162
| CAS No. | CATO-C4X-2213162 |
| Molecular Formula | C15H13BrO3 |
| Molecular Weight | 321.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Roxadustat Impurity 162 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Roxadustat Impurity 162 (CAS CATO-C4X-2213162), a pharmacopoeial impurity reference standard (molecular formula C15H13BrO3, MW 321.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system, Roxadustat Impurity 162 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 321.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H13BrO3 |
| Molecular Weight | 321.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Roxadustat Standards
- Roxadustat Impurity 143 (CAS CATO-C4X-2213143)
- Roxadustat Impurity 65 (CAS CATO-C4X-221365)
- Roxadustat impurity 111 (CAS CATO-C4X-2213111)
- Roxadustat Impurity 90 (CAS CATO-C4X-221390)
- Roxadustat Impurity 9 (CAS 2244489-54-9)
- Roxadustat Impurity 22 (CAS CATO-C4X-221322)
- Roxadustat Impurity 8 (CAS CATO-C4X-22138)
- Roxadustat Impurity 57 (CAS 38791-58-1)
Recommended Standards
- 938153-97-0 5-Bromo-2-[(2-methylbenzyl)oxy]benzoic acid MFCD09707674 (CAS 938153-97-0)
- Trifarotene Impurity 2 (CAS 895542-84-4)
- tert-Butyl 3-bromo-6-cyano-1H-indole-1-carboxylate (CAS 2089326-20-3)
- Tert-butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)carbamate (CAS 1032758-88-5)
- Eperisone Impurity 43 (CAS CATO-C4X-227943)
- Arginine impurity 11 (CAS CATO-C4X-242411)
- Tegoprazan Impurity 79 (CAS CATO-C4X-229779)
- Hexahydropyrazino[1,2-d][1,4]diazepine-1,9(2H,6H)-dione (CAS 130947-37-4)
- 7-Methyl-5-oxa-2-azaspiro[3.4]Octane (CAS 2306260-93-3)
- Benzyl tert-butyl (3-(4-bromophenyl)propane-1,2-diyl)(S)-dicarbamate (CAS 1253791-76-2)
- (4-Ethoxycarbonimidoyl-phenyl)-acetic acid ethyl ester; hydrochloride (CAS 52798-05-7)
- 4-Bromo-N,2-dimethyl-6-nitroaniline (CAS 1078136-88-5)
- 3-Ethynyl-2-methoxyaniline (CAS 1609394-02-6)
- C-telopeptide (CAS 162929-64-8)
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