Roxadustat Impurity 160 CAS CATO-C4X-2213160
| CAS No. | CATO-C4X-2213160 |
| Molecular Formula | C13H9BrO3 |
| Molecular Weight | 293.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roxadustat Impurity 160.
Roxadustat Impurity 160 (CAS CATO-C4X-2213160) is a certified pharmaceutical impurity reference standard with the molecular formula C13H9BrO3 and a molecular weight of 293.11 g/mol.
The molecular framework of Roxadustat Impurity 160 (C13H9BrO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Roxadustat Impurity 160 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9BrO3 |
| Molecular Weight | 293.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Roxadustat Standards
- Roxadustat Impurity 12 (CAS CATO-C4X-221312)
- Roxadustat Impurity N14 (CAS 2243809-28-9)
- Roxadustat Impurity 64 (CAS 1509958-11-5)
- Roxadustat Impurity 9 (CAS 1421312-35-7)
- Roxadustat Impurity 99 (CAS CATO-C4X-221399)
- Roxadustat Impurity N15 (CAS 1455091-10-7)
- Roxadustat Impurity 164 (CAS CATO-C4X-2213164)
- Roxadustat Impurity 43 (CAS CATO-C4X-221343)
Recommended Standards
- 4906-68-7 CTK1D8664 [1,1'-Biphenyl]-3-carboxylicacid, 5-bromo-4-hydroxy- (CAS 4906-68-7)
- 2,4-Dichloro-6-(4-fluorophenyl)quinazoline (CAS 1003042-27-0)
- 7-Bromo-1,2-dihydronaphtho[2,1-b]furan-2-carboxylic acid (CAS 927800-76-8)
- 6-(4-Bromophenoxy)nicotinamide (CAS 1016671-78-5)
- Empagliflozin Impurity 284 (CAS 1711323-05-5)
- Bilastine Impurity 51 (CAS 2767509-03-3)
- Cinchocaine EP Impurity A (CAS 87864-14-0)
- 3-Bromo-6-chloro-2,4-difluorobenzaldehyde (CAS 1160573-58-9)
- 7-(2,2,2-Trifluoroacetyl)-1,2,3,6-tetrahydro-5H-pyrrolo[1,2-a]imidazol-5-one (CAS 1263215-92-4)
- 1H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridine (CAS 107457-74-9)
- [methyl(pyridin-3-ylsulfonyl)amino]acetic acid (CAS 1017029-42-3)
- 2-Butyl-2-trifluoromethyl-hexanoic acid (CAS 1365969-02-3)
- (1S,2R)-2-aminocycloheptane-1-carboxylic acid hydrochloride (CAS 522644-09-3)
- Tirzepatide Impurity 44 (CAS CATO-C4X-324044)
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