Roxadustat Impurity 171 CAS CATO-C4X-2213171
| CAS No. | CATO-C4X-2213171 |
| Molecular Formula | C14H12BrNO5 |
| Molecular Weight | 354.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roxadustat Impurity 171 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Roxadustat Impurity 171 (CAS CATO-C4X-2213171, C14H12BrNO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Roxadustat Impurity 171 (C14H12BrNO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 354.15 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H12BrNO5 |
| Molecular Weight | 354.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 15 (CAS CATO-C4X-221315)
- Roxadustat Impurity 172 (CAS CATO-C4X-2213172)
- Roxadustat Impurity 156 (CAS CATO-C4X-2213156)
- Roxadustat Impurity 29 (CAS 1959587-34-8)
- Roxadustat (CAS 808118-40-3)
- Roxadustat Impurity 1 (CAS 2301113-15-3)
- Roxadustat Impurity 20 (CAS 2599284-48-5)
- Roxadustat Impurity 31 (CAS 808118-34-5)
Recommended Standards
- Methyl 5-bromo-4-(furan-2-carboxamido)-2-methoxybenzoate (CAS 477889-85-3)
- tert-Butyl (1-(4-bromophenyl)-2,2,2-trifluoroethyl)carbamate (CAS 1129541-06-5)
- Ethyl 2-[(6-bromo-2-oxo-2H-chromen-3-yl)formamido]acetate (CAS 866155-17-1)
- (3-Bromo-5-trifluoromethyl-phenyl)-methyl-carbamic acid tert-butyl ester (CAS 1187928-24-0)
- Gatifloxacin Impurity 3 (CAS 616205-76-6)
- CAS 230615-12-0 (CAS 230615-12-0)
- Atorvastatin Impurity N2 (CAS 40281-50-3)
- 4-Nitronaphthalen-2-ol (CAS 38396-08-6)
- N-(5-Tert-butyl-2-methoxyphenyl)-2-chloroacetamide (CAS 379255-41-1)
- (1,3-Dithian-2-yl)triisopropylsilane (CAS 145251-89-4)
- (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis(2-methoxyphenyl)phosphino]ferrocene (CAS 1012866-12-4)
- 4-Chloro-6-iodoindoline-2,3-dione (CAS 139422-24-5)
- Methyl 4,7-dibromo-3-methoxy-2-naphthoate (CAS 175204-91-8)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
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