Roxadustat Impurity 53 CAS CATO-C4X-221353
| CAS No. | CATO-C4X-221353 |
| Molecular Formula | C18H14ClNO4 |
| Molecular Weight | 343.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roxadustat Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Roxadustat Impurity 53 (CAS CATO-C4X-221353), a pharmacopoeial impurity reference standard (molecular formula C18H14ClNO4, MW 343.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Roxadustat Impurity 53 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H14ClNO4 |
| Molecular Weight | 343.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 30 (CAS CATO-C4X-221330)
- Roxadustat Impurity 142 (CAS CATO-C4X-2213142)
- Roxadustat Impurity 60 (CAS CATO-C4X-221360)
- Roxadustat Impurity 106 (CAS CATO-C4X-2213106)
- Roxadustat Impurity 178 (CAS CATO-C4X-2213178)
- Roxadustat Desmethyl (CAS 708263-68-7)
- Roxadustat Impurity 58 (CAS CATO-C4X-205858)
- Roxadustat Impurity 55 (CAS CATO-C4X-221355)
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