Roxadustat Impurity 30 CAS CATO-C4X-221330
| CAS No. | CATO-C4X-221330 |
| Molecular Formula | C18H14ClNO4 |
| Molecular Weight | 343.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roxadustat Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Roxadustat Impurity 30 (CAS CATO-C4X-221330, C18H14ClNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Roxadustat Impurity 30 (C18H14ClNO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H14ClNO4 |
| Molecular Weight | 343.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 53 (CAS CATO-C4X-221353)
- Roxadustat Impurity 142 (CAS CATO-C4X-2213142)
- Roxadustat Impurity 60 (CAS CATO-C4X-221360)
- Roxadustat Impurity 106 (CAS CATO-C4X-2213106)
- Roxadustat Impurity 178 (CAS CATO-C4X-2213178)
- Roxadustat Desmethyl (CAS 708263-68-7)
- Roxadustat Impurity 58 (CAS CATO-C4X-205858)
- Roxadustat Impurity 55 (CAS CATO-C4X-221355)
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