Roxadustat Impurity 58 CAS CATO-C4X-221358
| CAS No. | CATO-C4X-221358 |
| Molecular Formula | C14H10O2S |
| Molecular Weight | 242.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Roxadustat Impurity 58 (CAS CATO-C4X-221358), a pharmacopoeial impurity reference standard (molecular formula C14H10O2S, MW 242.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Roxadustat Impurity 58 (C14H10O2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 242.29 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H10O2S |
| Molecular Weight | 242.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Sulfur Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 42 (CAS CATO-C4X-221342)
- Roxadustat Impurity 166 (CAS CATO-C4X-2213166)
- Roxadustat Impurity 116 (CAS CATO-C4X-2213116)
- Roxadustat Impurity 41 (CAS CATO-C4X-221341)
- Roxadustat Impurity N2 (CAS 57830-14-5)
- Roxadustat Impurity 161 (CAS CATO-C4X-2213161)
- Roxadustat Impurity 81 (CAS CATO-C4X-221381)
- Roxadustat Impurity 157 (CAS CATO-C4X-2213157)
Recommended Standards
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- 7-(2-Methylphenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one (CAS 1030120-83-2)
- Calcitriol Impurity 30 (CAS 69389-87-3)
- Drotaverine Impurity 24 (CAS CATO-C4X-243524)
- Parecoxib Impurity 74 (CAS CATO-C4X-159174)
- 2-Amino-N-(2-methoxypyridin-3-yl)-2-methylpentanamide (CAS 1179722-76-9)
- Calcium tetraborate (CAS 12007-56-6)
- 2-Hydroxy-4,6-dimethoxybenzoic acid, 97% (CAS 3187-19-7)
- Metaraminol Impurity 39 (CAS CATO-C4X-225239)
- 2-(Furan-2-yl)quinoline-4-carbohydrazide (CAS 345218-20-4)
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