Roxadustat Impurity 42 CAS CATO-C4X-221342
| CAS No. | CATO-C4X-221342 |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Roxadustat Impurity 42 (CAS CATO-C4X-221342, C14H12O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system, Roxadustat Impurity 42 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 244.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Roxadustat Standards
- Roxadustat Impurity 58 (CAS CATO-C4X-221358)
- Roxadustat Impurity 166 (CAS CATO-C4X-2213166)
- Roxadustat Impurity 116 (CAS CATO-C4X-2213116)
- Roxadustat Impurity 41 (CAS CATO-C4X-221341)
- Roxadustat Impurity 161 (CAS CATO-C4X-2213161)
- Roxadustat Impurity N2 (CAS 57830-14-5)
- Roxadustat Impurity 81 (CAS CATO-C4X-221381)
- Roxadustat Impurity 157 (CAS CATO-C4X-2213157)
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