Baricitinib Impurity 112 CAS CATO-C4X-2260112
| CAS No. | CATO-C4X-2260112 |
| Molecular Formula | C13H14ClN5O2S |
| Molecular Weight | 339.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Baricitinib Impurity 112 (CAS CATO-C4X-2260112, C13H14ClN5O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Baricitinib Impurity 112 (C13H14ClN5O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14ClN5O2S |
| Molecular Weight | 339.80 g/mol |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Baricitinib Standards
- Baricitinib Impurity 119 (CAS 2089575-87-9)
- Baricitinib Impurity 59 (CAS CATO-C4X-226059)
- Baricitinib Impurity 113 (CAS 1911644-33-1)
- Baricitinib impurity 99 (CAS 894807-98-8)
- Baricitinib Impurity 2 (CAS 2964606-44-6)
- Baricitinib Impurity 65 (CAS 1187594-29-1)
- Baricitinib Impurity 80 (CAS CATO-C4X-226080)
- Baricitinib Impurity N4 (CAS 442847-52-1)
Recommended Standards
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- 2,3,5-Tribromobenzonitrile (CAS 1006593-84-5)
- Montelukast Impurity 44 (CAS 2365398-66-7)
- Sitafloxacin impurity 57 (CAS CATO-C4X-115557)
- Vildagliptin Impurity 75 (CAS 1710765-32-4)
- 2-Ethylmalonamide (CAS 6082-49-1)
- 1-Amino-2-benzoylanthracene-9,10-dione (CAS 6337-19-5)
- (2,5-Dimethoxyphenyl)(phenyl)methanone (CAS 4038-13-5)
- 4-(2-Bromo-1,1,2,2-tetrafluoroethoxy)benzonitrile (CAS 957372-61-1)
- Methyl 5-(4-Hydroxyphenyl)pentanoate (CAS 64201-30-5)
- 5-Bromo-2-(methylsulfonyl)pyrimidin-4-amine (CAS 1379324-53-4)
- Fibrinopeptide B (human) (CAS 36204-23-6)
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