Baricitinib Impurity 126 CAS CATO-C4X-2260126
| CAS No. | CATO-C4X-2260126 |
| Molecular Formula | C16H11ClN2 |
| Molecular Weight | 266.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Baricitinib Impurity 126 (CAS CATO-C4X-2260126, C16H11ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Baricitinib Impurity 126 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 266.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClN2 |
| Molecular Weight | 266.72 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Baricitinib Standards
- Baricitinib Impurity 14 (CAS 1029716-44-6)
- Baricitinib Impurity 73 (CAS CATO-C4X-226073)
- Baricitinib Impurity 75 (CAS CATO-C4X-226075)
- Baricitinib Impurity 23 (CAS 1146629-75-5)
- Baricitinib Impurity 45 (CAS 2166596-69-4)
- Baricitinib Impurity 104 (CAS CATO-C4X-2260104)
- Baricitinib Impurity 78 (CAS 2055723-11-8)
- Baricitinib Impurity 28 (CAS CATO-C4X-226028)
Recommended Standards
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- rac-Atomoxetine EP Impurity D HCl (CAS 873310-28-2)
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- Ozenoxacin Impurity 51 (CAS CATO-C4X-279651)
- Morphine Methylsulfonate (CAS 1414808-25-5)
- (2-(6-(Cyclopropylamino)pyridin-3-yl)piperidin-1-yl)(phenyl)methanone (CAS 1352526-07-8)
- 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-5-(pyridin-4-yl)pyrimidin-4-amine (CAS 402595-29-3)
- 3-Aminocyclohexane-1-carboxylic acid hydrochloride (CAS 712317-16-3)
- 6-Methoxyisoquinoline-3-carbonitrile (CAS 1780824-60-3)
- Ubidecarenone impurity 19 (CAS 5677-54-3)
- Hexapeptide-9 (CAS 1228371-11-6)
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