Larotrectinib Impurity 13 CAS CATO-C4X-238013
| CAS No. | CATO-C4X-238013 |
| Molecular Formula | C32H26F4N10 |
| Molecular Weight | 626.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Larotrectinib Impurity 13 (CAS CATO-C4X-238013) is a certified pharmaceutical impurity reference standard with the molecular formula C32H26F4N10 and a molecular weight of 626.61 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Larotrectinib Impurity 13 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 626.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H26F4N10 |
| Molecular Weight | 626.61 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 10 |
Related Larotrectinib Standards
- Larotrectinib Impurity 20 (CAS CATO-C4X-238020)
- Larotrectinib Impurity 11 (CAS 3040394-58-6)
- Larotrectinib Sulfate (CAS 1223405-08-0)
- Larotrectinib Impurity 18 (CAS CATO-C4X-238018)
- Larotrectinib Impurity 10 (CAS 2753097-86-6)
- Larotrectinib Impurity 14 (CAS CATO-C4X-238014)
- Larotrectinib Impurity 19 (CAS CATO-C4X-238019)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
- Salbutamol Impurity 126 (CAS CATO-C4X-1176126)
- IDX-184, >98% (HPLC) (CAS 1036915-08-8)
- MC-Gly-Gly-BPA-NHS ester (CAS 2413428-37-0)
- N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide (CAS 1613028-81-1)
- Calcitonin Impurity 15 (CAS CATO-C4X-221815)
- Lufenuron EP Impurity E (CAS 103015-79-8)
- Imatinib Impurity 81 HCl (CAS 1207534-99-3)
- 2,6-Dichloro-4-fluorocinnamic acid (CAS 1807314-16-4)
- 2-(2-Bromophenyl)-1,2,3,4-tetrahydroquinolin-4-amine (CAS 1923082-52-3)
- BrettPhos Pd G1 (CAS 1148148-01-9)
- 6-Chloro-9-(4-chlorobut-2-yn-1-yl)-9H-purin-2-amine (CAS 121653-93-8)
- 6-(3-Fluorophenyl)-5-methyl-3-pyridinylamine (CAS 1214373-18-8)
- Ethyl 8-methoxy-2-oxo-2H-chromene-3-carboxylate (CAS 1729-02-8)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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