Larotrectinib Impurity 14 CAS CATO-C4X-238014
| CAS No. | CATO-C4X-238014 |
| Molecular Formula | C21H24F2N6O3 |
| Molecular Weight | 446.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Larotrectinib Impurity 14 (CAS CATO-C4X-238014) is a certified pharmaceutical impurity reference standard with the molecular formula C21H24F2N6O3 and a molecular weight of 446.45 g/mol.
The molecular framework of Larotrectinib Impurity 14 (C21H24F2N6O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Larotrectinib Impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H24F2N6O3 |
| Molecular Weight | 446.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Larotrectinib Standards
- Larotrectinib Impurity 19 (CAS CATO-C4X-238019)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
- Larotrectinib impurity 5 (CAS 2135871-21-3)
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 1 (CAS 1223404-68-9)
- Larotrectinib Impurity 2 (CAS 2409589-59-7)
Recommended Standards
- Nicardipine Impurity 66 (CAS CATO-C4X-171066)
- Enzalutamide Impurity 16 (CAS 915087-16-0)
- 1,3-Bis(diphenylphosphaneyl)benzene (CAS 1179-05-1)
- N-Fmoc-L-HomoPhe(4-NO2)-OH (CAS 205182-66-7)
- Oxaliplatin EP Impurity C (CAS 111321-67-6)
- Varenicline Impurity 53 (CAS CATO-C4X-196253)
- Ropivacaine Impurity 34 (CAS 175888-75-2)
- 5,6,7,8-Tetrahydro-3H-pyrido[4,3-c][1,2,6]thiadiazine 2,2-dioxide hydrochloride (CAS 2138572-96-8)
- Regorafenib Impurity 51 (CAS 399-96-2)
- 5-cyclobutyl-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole (CAS 680216-02-8)
- 2-(((2,5-Dichlorobenzyl)oxy)methyl)pyrrolidine hydrochloride (CAS 1289388-39-1)
- 3-Amino-1-hydroxy-7-methyl-3,4-dihydroquinolin-2(1H)-one (CAS 1258545-61-7)
- (4-Chlorophenyl)(3,5-difluorobenzyl)sulfane (CAS 259132-16-6)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com