Larotrectinib Impurity 20 CAS CATO-C4X-238020
| CAS No. | CATO-C4X-238020 |
| Molecular Formula | C32H26F4N10O |
| Molecular Weight | 642.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Larotrectinib Impurity 20 (CAS CATO-C4X-238020), a pharmacopoeial impurity reference standard (molecular formula C32H26F4N10O, MW 642.61 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Larotrectinib Impurity 20 (C32H26F4N10O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H26F4N10O |
| Molecular Weight | 642.61 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 10 |
Related Larotrectinib Standards
- Larotrectinib Impurity 11 (CAS 3040394-58-6)
- Larotrectinib Impurity 13 (CAS CATO-C4X-238013)
- Larotrectinib Sulfate (CAS 1223405-08-0)
- Larotrectinib Impurity 18 (CAS CATO-C4X-238018)
- Larotrectinib Impurity 10 (CAS 2753097-86-6)
- Larotrectinib Impurity 14 (CAS CATO-C4X-238014)
- Larotrectinib Impurity 19 (CAS CATO-C4X-238019)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
- Bis(2,4,6-tribromophenyl)amine (CAS 64524-09-0)
- Relugolix Impurity 98 (CAS CATO-C4X-242998)
- APG 115 (CAS 1818393-16-6)
- Flomoxef Impurity 62 (CAS CATO-C4X-138262)
- Lansoprazole Impurity 12 (CAS 131926-97-1)
- Ethambutol Impurity 8 (CAS 2792161-95-4)
- Olanzapine Impurity 30 (CAS CATO-C4X-117830)
- Acridin-1-amine (CAS 578-06-3)
- Bzl-Gly-Oet (CAS 6436-90-4)
- Voclosporin-d4 (CAS CATO-C4X-199824)
- 14255-03-9 Calcium, isotope of mass 44 Calcium-44 44Ca (CAS 14255-03-9)
- 1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(sec-butyl)phenyl)amino)propan-1-one (CAS 882748-28-9)
- 2-Deoxy Cytidine-5,6-d (CAS 1186526-91-9)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com