Upadacitinib Impurity 185 CAS CATO-C4X-2405185
| CAS No. | CATO-C4X-2405185 |
| Molecular Formula | C13H10BrN3O2S |
| Molecular Weight | 352.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Upadacitinib Impurity 185 (CAS CATO-C4X-2405185) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10BrN3O2S and a molecular weight of 352.21 g/mol.
Upadacitinib Impurity 185 (C13H10BrN3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10BrN3O2S |
| Molecular Weight | 352.21 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 17 (CAS 1201186-54-0)
- Upadacitinib Impurity 33 (CAS 2650489-66-8)
- Upadacitinib Impurity 113 (CAS CATO-C4X-2405113)
- Upadacitinib Impurity 116 (CAS CATO-C4X-2405116)
- Upadacitinib Impurity 160 (CAS CATO-C4X-2405160)
- Upadacitinib Impurity 41 (CAS 2050038-78-1)
- Upadacitinib Impurity 16 (CAS 1428243-26-8)
- Upadacitinib Impurity 161 (CAS CATO-C4X-2405161)
Recommended Standards
- Benzyl 2,4-dichloro-5H,6H,7H,8H,9H-pyrimido[4,5-d]azepine-7-carboxylate (CAS 1207362-38-6)
- Lorazepam Impurity 20 (CAS CATO-C4X-104120)
- Tert-butyl 6'-bromo-1'-oxo-1',3'-dihydrospiro[azetidine-3,2'-indene]-1-carboxylate (CAS 1245523-49-2)
- N-(3-acetylphenyl)-2-(2,4-dichlorophenoxy)propanamide (CAS 292644-25-8)
- Ergometrine EP Impurity G (CAS 361-37-5)
- Azilsartan Impurity 10 (CAS 1863930-34-0)
- Methyldopa Impurity 12 (CAS CATO-C4X-169312)
- 5-formylthiazole-2-carbonitrile (CAS 2090886-23-8)
- 1-(2-Bromo-4,5-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride (CAS 1049758-71-5)
- Methyl 2-(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)acetate (CAS 1365942-09-1)
- 7-Biopterin (CAS 13019-53-9)
- 2,4,7-Trimethylbenzo[b][1,8]naphthyridin-5-ol (CAS 82756-19-2)
- N-Benzyl-5-nitroquinazolin-4-amine (CAS 169205-61-2)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
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