Upadacitinib Impurity 187 CAS CATO-C4X-2405187
| CAS No. | CATO-C4X-2405187 |
| Molecular Formula | C8H13BrN2O2 |
| Molecular Weight | 249.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Upadacitinib Impurity 187 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Upadacitinib Impurity 187 (CAS CATO-C4X-2405187, C8H13BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Upadacitinib Impurity 187 (C8H13BrN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H13BrN2O2 |
| Molecular Weight | 249.11 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Upadacitinib Standards
- Upadacitinib Impurity 11 (CAS 1708997-43-6)
- Upadacitinib Impurity 176 (CAS CATO-C4X-2405176)
- Upadacitinib Impurity 177 (CAS CATO-C4X-2405177)
- Upadacitinib Impurity 97 (CAS CATO-C4X-240597)
- Upadacitinib Impurity 218 (CAS 117718-83-9)
- Upadacitinib Impurity 123 (CAS CATO-C4X-2405123)
- Upadacitinib Impurity 75 (CAS CATO-C4X-240575)
- Upadacitinib Impurity 129 (CAS CATO-C4X-2405129)
Recommended Standards
- 898761-15-4 5-Chloro-1-(3-chloro-4-fluorophenyl)pentan-1-one DTXSID00645157 (CAS 898761-15-4)
- Ethyl 2-bromo-2-(thiophen-2-yl)acetate (CAS 104688-01-9)
- 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965 (CAS 849068-61-7)
- Methyl 4-bromo-5-ethylthiophene-2-carboxylate (CAS 1047645-89-5)
- Dotinurad Impurity 109 (CAS 1285572-82-8)
- Saxagliptin Impurity 52 HCl (CAS 709031-43-6(free base))
- Enzalutamide Impurity 56 (CAS CATO-C4X-101656)
- 3-Bromobenzothioamide (CAS 2227-62-5)
- tert-Butyl (4-bromo-3-chloro-2-methylphenyl)carbamate (CAS 1881328-92-2)
- 4-Chloro-3-(triethylsilyl)pyridine (CAS 123506-94-5)
- 51541-08-3 2-Propenoic acid, 2-methyl-, 2-oxiranylmethyl ester, polymer with ethene and methyl 2-propenoate 2-Propenoic acid, 2-methyl-, oxiranylmethyl ester, polymer with ethene and methyl 2-propenoate (CAS 51541-08-3)
- (Butan-2-yl)[(2,5-dimethoxyphenyl)methyl]amine hydrochloride (CAS 1240572-46-6)
- 3-(3-Acetyl-2,4-dimethyl-1h-pyrrol-1-yl)propanoic acid (CAS 842973-07-3)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com