Upadacitinib Impurity 181 CAS CATO-C4X-2405181
| CAS No. | CATO-C4X-2405181 |
| Molecular Formula | C18H21N3O3 |
| Molecular Weight | 327.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Upadacitinib Impurity 181 (CAS CATO-C4X-2405181), a pharmacopoeial impurity reference standard (molecular formula C18H21N3O3, MW 327.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Upadacitinib Impurity 181 (C18H21N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H21N3O3 |
| Molecular Weight | 327.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Upadacitinib Standards
- Upadacitinib Impurity 101 (CAS CATO-C4X-2405101)
- Upadacitinib Impurity 143 (CAS CATO-C4X-2405143)
- Upadacitinib Impurity 196 (CAS CATO-C4X-2405196)
- Upadacitinib Impurity 1 (CAS CATO-C4X-24051)
- Upadacitinib Impurity 59 (CAS 2411540-28-6)
- Upadacitinib Impurity 194 (CAS CATO-C4X-2405194)
- Upadacitinib Impurity 152 (CAS CATO-C4X-2405152)
- Upadacitinib Impurity 154 (CAS CATO-C4X-2405154)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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