Upadacitinib Impurity 188 CAS CATO-C4X-2405188
| CAS No. | CATO-C4X-2405188 |
| Molecular Formula | C6H3BrN4O |
| Molecular Weight | 227.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Upadacitinib Impurity 188.
CATO supplies Upadacitinib Impurity 188 (CAS CATO-C4X-2405188), a pharmacopoeial impurity reference standard (molecular formula C6H3BrN4O, MW 227.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Upadacitinib Impurity 188 (C6H3BrN4O) contains an amide group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 227.02 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Upadacitinib Impurity 188 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3BrN4O |
| Molecular Weight | 227.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Upadacitinib Standards
- Upadacitinib Impurity 122 (CAS CATO-C4X-2405122)
- Upadacitinib Impurity 54 (CAS 406-11-1)
- Upadacitinib Impurity 129 (CAS CATO-C4X-2405129)
- Upadacitinib Impurity 222 (CAS CATO-C4X-2405222)
- Upadacitinib Impurity 75 (CAS CATO-C4X-240575)
- Upadacitinib Impurity 218 (CAS 117718-83-9)
- Upadacitinib Impurity 67 (CAS CATO-C4X-240567)
- Upadacitinib Impurity 187 (CAS CATO-C4X-2405187)
Recommended Standards
- 3-(5-Bromopyrimidin-2-yl)-1,2,4-oxadiazole (CAS 2098092-67-0)
- 6-Bromo-2-fluoroquinoxaline (CAS 112080-07-6)
- 2-(Benzo[d][1,3,2]dioxaborol-2-yloxy)aniline (CAS 93969-80-3)
- 6-Bromo-7-fluoroquinoxaline (CAS 1210047-55-4)
- Cefuroxime Impurity 40 (CAS CATO-C4X-124540)
- Indobufen Impurity 47 (CAS 769-68-6)
- Olmesartan impurity 100 (CAS 761404-82-4)
- Delfaprazine (CAS 117827-81-3)
- Ethyl 2-(bis(benzyloxy)phosphoryl)acetate (CAS 69639-67-4)
- 3-(Dimethylamino)acrylonitrile (CAS 2407-68-3)
- 1-(2-Hydroxy-4-iodophenyl)ethan-1-one (CAS 39730-66-0)
- 4-Amino-6-chloropyridine-3-carbaldehyde, 97% (CAS 1001756-21-3)
- (1-((3-Methylthiophen-2-yl)methyl)piperidin-3-yl)methanamine (CAS 1247524-92-0)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com