Upadacitinib Impurity 201 CAS CATO-C4X-2405201
| CAS No. | CATO-C4X-2405201 |
| Molecular Formula | C3H5F3N2O |
| Molecular Weight | 142.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Upadacitinib Impurity 201.
As a process- or degradation-related impurity, Upadacitinib Impurity 201 (CAS CATO-C4X-2405201, C3H5F3N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Upadacitinib Impurity 201 (C3H5F3N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C3H5F3N2O |
| Molecular Weight | 142.08 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Upadacitinib Standards
- Upadacitinib Impurity 163 (CAS CATO-C4X-2405163)
- Upadacitinib Impurity 68 (CAS CATO-C4X-240568)
- Upadacitinib Impurity 89 (CAS CATO-C4X-240589)
- Upadacitinib Impurity 202 (CAS CATO-C4X-2405202)
- Upadacitinib Impurity 151 (CAS CATO-C4X-2405151)
- Upadacitinib Impurity 142 (CAS CATO-C4X-2405142)
- Upadacitinib Impurity 159 (CAS CATO-C4X-2405159)
- Upadacitinib Impurity 164 (CAS CATO-C4X-2405164)
Recommended Standards
- Ethyl Trifluoroacetate (CAS 383-63-1)
- 3-Fluoro-5-nitropyridine (CAS 1060804-39-8)
- 1-(2,2,2-Trifluoroethoxy)ethan-1-one 2,2,2-Trifluoroethyl ethanoate 2-Acetoxy-1,1,1-trifluoroethane 406-95-1 trifluoroethyl acetate (CAS 406-95-1)
- 2-Fluoro-6-nitropyridine (CAS 1082042-27-0)
- Dinoprost EP Impurity B (CAS 37658-84-7)
- Apixaban Impurity 26 (CAS 1643330-62-4)
- Trametinib Impurity 17 (CAS CATO-C4X-278217)
- 2,5-Difluoro-4-hydroxybenzonitrile (CAS 887267-05-2)
- 8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-ol (CAS 2621932-46-3)
- 2-chloro-N-{4-chloro-3-[(dimethylamino)sulfonyl]phenyl}propanamide (CAS 929973-64-8)
- Ethanaminium, N,N,N-trimethyl-2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]-, sulfate, polymer with 2-propenamide (CAS 72361-52-5)
- 4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-carbonitrile (CAS 590409-82-8)
- (1R,1's,4R,4'R)-4-(4-methoxyphenyl)-4'-propyl-1,1'-bi(cyclohexane) (CAS 84655-98-1)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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