Upadacitinib Impurity 37 CAS CATO-C4X-240537
| CAS No. | CATO-C4X-240537 |
| Molecular Formula | C18H21F3N6O2 |
| Molecular Weight | 410.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Upadacitinib Impurity 37 (C18H21F3N6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Upadacitinib Impurity 37 (CAS CATO-C4X-240537), a pharmacopoeial impurity reference standard (molecular formula C18H21F3N6O2, MW 410.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H21F3N6O2 |
| Molecular Weight | 410.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Upadacitinib Standards
- Upadacitinib Impurity 58 (CAS CATO-C4X-240558)
- Upadacitinib Impurity 47 (CAS 1428243-28-0)
- Upadacitinib Impurity 76 (CAS 2270173-67-4)
- Upadacitinib Impurity 108 (CAS CATO-C4X-2405108)
- Upadacitinib Impurity 94 (CAS CATO-C4X-240594)
- Upadacitinib Impurity 36 (CAS CATO-C4X-240536)
- Upadacitinib Impurity 38 (CAS CATO-C4X-240538)
- Upadacitinib Impurity 138 (CAS CATO-C4X-2405138)
Recommended Standards
- NVP-BKM 120 (CAS 944396-07-0)
- SIRT6-IN-1 (CAS 1214468-35-5)
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- Posaconazole Impurity 89 (CAS CATO-C4X-1208189)
- Atogepant Impurity 34 (CAS 1456803-29-4)
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- 2-(Chloromethyl)-6-methylbenzonitrile (CAS 1261780-69-1)
- 6,8-Difluorospiro[chroman-2,1'-cyclobutan]-4-amine (CAS 934554-70-8)
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- (+)-Dihydrocarvone（mixture of isomers） (CAS 7764-50-3)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
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