Upadacitinib Impurity 138 CAS CATO-C4X-2405138
| CAS No. | CATO-C4X-2405138 |
| Molecular Formula | C22H25N5O3 |
| Molecular Weight | 407.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Upadacitinib Impurity 138.
As a process- or degradation-related impurity, Upadacitinib Impurity 138 (CAS CATO-C4X-2405138, C22H25N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H25N5O3, Upadacitinib Impurity 138 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 407.47 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25N5O3 |
| Molecular Weight | 407.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Upadacitinib Standards
- Upadacitinib Impurity 6 (CAS CATO-C4X-24056)
- Upadacitinib Impurity 36 (CAS CATO-C4X-240536)
- Upadacitinib Impurity 38 (CAS CATO-C4X-240538)
- Upadacitinib Impurity 108 (CAS CATO-C4X-2405108)
- Upadacitinib Impurity 94 (CAS CATO-C4X-240594)
- Upadacitinib Impurity 47 (CAS 1428243-28-0)
- Upadacitinib Impurity 76 (CAS 2270173-67-4)
- Upadacitinib Impurity 37 (CAS CATO-C4X-240537)
Recommended Standards
- Tofacitinib Impurity 19 (CAS CATO-C4X-107919)
- Valsartan Impurity 84 (CAS CATO-C4X-105784)
- Ethyl 1-({4-oxo-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxalin-7-yl}sulfonyl)piperidine-4-carboxylate (CAS 1008946-98-2)
- Valsartan Impurity 61 (CAS 137862-57-8)
- Rifampicin EP Impurity A (CAS 13983-13-6)
- Clonixin Impurity 2 (CAS CATO-C4X-33852)
- Lapatinib Impurity 41 (CAS CATO-C4X-119141)
- 6-(Cyclohex-2-en-1-yl)hexanoic acid (CAS 2105-35-3)
- n-((1,2,3-Thiadiazol-4-yl)methyl)butan-1-amine (CAS 1156892-46-4)
- 4-Chloro-6-(2,6-difluorophenyl)pyrimidine (CAS 405930-78-1)
- 4-Hydroxy-1,2-oxathiolane 2,2-dioxide (CAS 10200-48-3)
- (S)-1-(4-Chloro-3-(trifluoromethyl)phenyl)propan-1-amine (CAS 1213160-49-6)
- Lurasidone Impurity 43 2HCl (CAS 1260025-93-1)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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