Lifitegrast Impurity 156 CAS CATO-C4X-2409156
| CAS No. | CATO-C4X-2409156 |
| Molecular Formula | C19H17BrCl2N2O3 |
| Molecular Weight | 472.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Lifitegrast Impurity 156 (CAS CATO-C4X-2409156), a pharmacopoeial impurity reference standard (molecular formula C19H17BrCl2N2O3, MW 472.16 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lifitegrast Impurity 156 (C19H17BrCl2N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17BrCl2N2O3 |
| Molecular Weight | 472.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Lifitegrast Standards
- Lifitegrast Impurity 157 (CAS CATO-C4X-2409157)
- Lifitegrast Impurity N12 (CAS 851785-70-1)
- Lifitegrast Impurity 69 (CAS CATO-C4X-240969)
- Lifitegrast impurity 92 (CAS CATO-C4X-240992)
- Lifitegrast Impurity 25 (CAS CATO-C4X-240925)
- Lifitegrast Impurity 158 (CAS CATO-C4X-2409158)
- Lifitegrast Impurity 44 (CAS CATO-C4X-240944)
- Lifitegrast Impurity 46 (CAS CATO-C4X-240946)
Recommended Standards
- N-(2-bromophenyl)-2-(3,4-dichlorophenyl)quinoline-4-carboxamide (CAS 332176-53-1)
- 6,8-Dibromo-3-(3,4-dimethylbenzenesulfonyl)-2H-chromen-2-one (CAS 866013-15-2)
- (S)-6,6’-Dibromo-2,2’-dimethoxy-1,1’-binaphthalene (CAS 117745-41-2)
- 4-Chloro-N-(furan-2-ylmethyl)-N-(2-oxo-2-((2,4,6-trichlorophenyl)amino)ethyl)benzamide (CAS 337496-22-7)
- Amoroven EP impurity L TFA Salt (CAS CATO-C4X-154222)
- Thiamine /Vitamin B1 Impurity 48 (CAS CATO-C4X-187348)
- Gadobutrol Impurity 7 (CAS CATO-C4X-21207)
- 5-Methyl-3-(methylsulfanyl)-1,2-thiazole-4-carboxylic acid (CAS 338778-85-1)
- 4,4＇-Bis(isocyanatophenyl)oxide (CAS 4128-73-8)
- N-(4-Fluoro-1H-indol-7-yl)acetamide (CAS 1357376-42-1)
- 3-(2-chloropyridin-3-yl)propanoic acid (CAS 1256822-91-9)
- 1-Bromo-3,5-difluoro-2-iodobenzene (CAS 175278-11-2)
- N-(2-acetylphenyl)-4-bromobenzenesulfonamide (CAS 303152-39-8)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com