Lifitegrast Impurity N12 CAS 851785-70-1
| CAS No. | 851785-70-1 |
| Molecular Formula | C20H20Cl2N2O5S |
| Molecular Weight | 471.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Lifitegrast Impurity N12 (C20H20Cl2N2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 471.35 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lifitegrast Impurity N12 (CAS 851785-70-1, C20H20Cl2N2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lifitegrast Impurity N12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20Cl2N2O5S |
| Molecular Weight | 471.35 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 156 (CAS CATO-C4X-2409156)
- Lifitegrast Impurity 157 (CAS CATO-C4X-2409157)
- Lifitegrast Impurity 69 (CAS CATO-C4X-240969)
- Lifitegrast impurity 92 (CAS CATO-C4X-240992)
- Lifitegrast Impurity 25 (CAS CATO-C4X-240925)
- Lifitegrast Impurity 158 (CAS CATO-C4X-2409158)
- Lifitegrast Impurity 44 (CAS CATO-C4X-240944)
- Lifitegrast Impurity 46 (CAS CATO-C4X-240946)
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- N-(3,4-Dichlorophenyl)-2-((5-(4-hydroxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332881-74-0)
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