Lifitegrast Impurity 74 CAS CATO-C4X-240974
| CAS No. | CATO-C4X-240974 |
| Molecular Formula | C14H21NO4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lifitegrast Impurity 74 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lifitegrast Impurity 74 (CAS CATO-C4X-240974, C14H21NO4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lifitegrast Impurity 74 (C14H21NO4SHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 335.84 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lifitegrast Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H21NO4S HCl |
| Molecular Weight | 335.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast (CAS 1025967-78-5)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Lifitegrast Impurity 49 (CAS 1194550-59-8)
- Lifitegrast Impurity 30 (CAS 1194550-61-2)
- Lifitegrast Impurity 23 (CAS 1194550-65-6)
- Lifitegrast Impurity 11 (CAS 1194550-67-8)
- Lifitegrast Impurity 39 (CAS 1194864-16-8)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
Recommended Standards
- Resmetirom Impurity 34 (CAS CATO-C4X-291234)
- Apremilast Impurity 47 (CAS 1956-36-1)
- Flurbiprofen Impurity 91 (CAS CATO-C4X-144491)
- 1-(4-Bromophenyl)-3-(2-chloroethyl)urea (CAS 15145-38-7)
- H-Orn(Boc)-OMe · HCl (CAS 2480-96-8)
- (R)-2-Chloro-4-methylcyclohex-1-ene-1-carbaldehyde (CAS 2760537-46-8)
- 2-(1H-1,2,4-Triazol-1-yl)-N-{[3-(trifluoromethyl)phenyl]methyl}acetamide (CAS 672950-16-2)
- Anamorelin Hydrochloride (CAS 861998-00-7)
- 5-Methylchromane-6-carboxylic acid (CAS 20006-76-2)
- Semaglutide impurity 104(Fmoc-D-His-Aib) (CAS 2171211-18-8)
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