4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(N,N-dimethylsulfamoyl)phenyl)piperazine-1-carboxamide CAS 692733-09-8
| CAS No. | 692733-09-8 |
| Molecular Formula | C19H21ClF3N5O3S |
| Molecular Weight | 491.91 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(N,N-dimethylsulfamoyl)phenyl)piperazine-1-carboxamide is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(N,N-dimethylsulfamoyl)phenyl)piperazine-1-carboxamide (CAS 692733-09-8) is a high-purity analytical reference standard with the molecular formula C19H21ClF3N5O3S and a molecular weight of 491.91 g/mol.
The molecular framework of 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(N,N-dimethylsulfamoyl)phenyl)piperazine-1-carboxamide (C19H21ClF3N5O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21ClF3N5O3S |
| Molecular Weight | 491.91 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Chloro Standards
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- 7-Chloro-3-(3,4-dimethylbenzenesulfonyl)-N-(3,5-dimethylphenyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 893788-59-5)
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- N-(5-chloro-2-methylphenyl)-2-((5-(((2,6-dimethylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332911-63-4)
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Recommended Standards
- 3-[(4-Chlorophenyl)methanesulfinyl]-4-phenyl-5-{[3-(trifluoromethyl)phenoxy]methyl}-4H-1,2,4-triazole (CAS 956159-47-0)
- 1-(4-Chlorophenyl)-3-(4-ethyl-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)pyridazin-4(1H)-one (CAS 478077-63-3)
- Rimegepant Impurity 81 (CAS CATO-C4X-248781)
- Rimegepant Impurity 121 (CAS CATO-C4X-2487121)
- 2-((2,4-Dichlorobenzyl)amino)ethan-1-ol (CAS 6269-87-0)
- 4-hydroxy-6-nitroquinoline-3-carbonitrile (CAS 2305-65-9)
- Isopropyl N-[4-(2,4-dichlorobenzoyl)-1H-pyrrol-2-yl]carbamate (CAS 320419-36-1)
- Gadoxetate Impurity 10 (CAS CATO-C4X-261810)
- Ozagrel Impurity 6 (CAS 143945-86-2)
- N-{2-[(4-fluorophenyl)sulfanyl]ethyl}-3,4,5-trimethoxybenzamide (CAS 337920-96-4)
- 4-[3-(Methoxycarbonyl)-5-isoxazolyl]benzoic Acid (CAS 1375064-52-0)
- (S)-2-Amino-N-(4-(N-ethylacetamido)cyclohexyl)propanamide (CAS 1354009-19-0)
- 4-Methyl-4-phenylcyclohexan-1-amine hydrochloride (CAS 56327-27-6)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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