Dotinurad Impurity 187 CAS CATO-C4X-2494187
| CAS No. | CATO-C4X-2494187 |
| Molecular Formula | C14H11Cl2NO5S |
| Molecular Weight | 376.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Dotinurad Impurity 187 (CAS CATO-C4X-2494187) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11Cl2NO5S and a molecular weight of 376.21 g/mol.
The molecular framework of Dotinurad Impurity 187 (C14H11Cl2NO5S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11Cl2NO5S |
| Molecular Weight | 376.21 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Dotinurad Standards
- Dotinurad impurity 108 (CAS CATO-C4X-2494108)
- Dotinurad Impurity 60 (CAS CATO-C4X-249460)
- Dotinurad Impurity 189 (CAS CATO-C4X-2494189)
- Dotinurad Impurity 131 (CAS CATO-C4X-2494131)
- Dotinurad Impurity 66 (CAS CATO-C4X-249466)
- Dotinurad Impurity 1 (CAS 1285573-44-5)
- Dotinurad Impurity 124 (CAS 888730-55-0)
- Dotinurad Impurity 14 (CAS CATO-C4X-249414)
Recommended Standards
- Spiro[fluorene-9,9'-xanthen]-4-ylboronic acid (CAS 2244281-69-2)
- Diethyl 2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanedioate (CAS 55810-48-5)
- 5-Bromo-N-((3-(1-ethyl-1H-pyrrol-2-yl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide (CAS 2034502-84-4)
- N-(6-(4-bromophenyl)-2-oxo-2H-pyran-3-yl)thiophene-2-carboxamide (CAS 478048-98-5)
- Avibactam Impurity 59 (CAS CATO-C4X-134859)
- Noradrenaline EP Impurity E (CAS 54234-59-2)
- Diazoxide Impurity 19 (CAS CATO-C4X-195219)
- 3-Fluorobenzylphosphonic acid (CAS 80395-16-0)
- 5-Chloro-2-(piperidin-1-yl)aniline (CAS 412308-45-3)
- 2-Amino-4-cyclopropyl-thiophene-3-carboxylic acid ethyl ester (CAS 120109-75-3)
- 2-Methoxypyridine-4-carboximidamide hydrochloride (CAS 1679340-93-2)
- N-Cyclobutylaniline (CAS 155342-90-8)
- 1-(2-(4-Ethylphenoxy)acetyl)-4-((4-methylphenyl)sulfonyl)semicarbazide (CAS 1024439-41-5)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
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