Venetoclax Impurity 81 CAS CATO-C4X-249581
| CAS No. | CATO-C4X-249581 |
| Molecular Formula | C34H37ClN4O3 |
| Molecular Weight | 585.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Venetoclax Impurity 81 (C34H37ClN4O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Venetoclax Impurity 81 (CAS CATO-C4X-249581, C34H37ClN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C34H37ClN4O3 |
| Molecular Weight | 585.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Venetoclax Standards
- Venetoclax Impurity 41 (CAS CATO-C4X-249541)
- Venetoclax Impurity 142 (CAS CATO-C4X-2495142)
- Venetoclax Impurity 56 (CAS CATO-C4X-249556)
- Venetoclax Impurity 51 (CAS CATO-C4X-249551)
- Venetoclax Impurity 43 (CAS CATO-C4X-249543)
- Venetoclax Impurity 9 (CAS 1235865-77-6)
- Venetoclax Impurity 27 (CAS CATO-C4X-249527)
- Venetoclax Impurity 107 (CAS CATO-C4X-2495107)
Recommended Standards
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