Venetoclax Impurity 142 CAS CATO-C4X-2495142
| CAS No. | CATO-C4X-2495142 |
| Molecular Formula | C33H35ClN4O4 |
| Molecular Weight | 587.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Venetoclax Impurity 142 (CAS CATO-C4X-2495142), a pharmacopoeial impurity reference standard (molecular formula C33H35ClN4O4, MW 587.11 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Venetoclax Impurity 142 (C33H35ClN4O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C33H35ClN4O4 |
| Molecular Weight | 587.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Venetoclax Standards
- Venetoclax Impurity 56 (CAS CATO-C4X-249556)
- Venetoclax Impurity 41 (CAS CATO-C4X-249541)
- Venetoclax Impurity 81 (CAS CATO-C4X-249581)
- Venetoclax Impurity 51 (CAS CATO-C4X-249551)
- Venetoclax Impurity 27 (CAS CATO-C4X-249527)
- Venetoclax Impurity 67 (CAS CATO-C4X-249567)
- Venetoclax Impurity 65 (CAS CATO-C4X-249565)
- Venetoclax Impurity 43 (CAS CATO-C4X-249543)
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- Eldecalcitol Impurity 7 (CAS CATO-C4X-21407)
- Levosimendan Impurity 14 (CAS CATO-C4X-130814)
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- 1-chlorobicyclo[1.1.1]pentane (CAS 10555-50-7)
- 4-Bromo-2-chloro-6-methylbenzenesulfonyl chloride (CAS 1208076-76-9)
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