Indocyanine Green Impurity 33 CAS CATO-C4X-250333

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-250333
Molecular FormulaC18H20NO4S
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Indocyanine Green Impurity 33 CAS CATO-C4X-250333 chemical structure

Description

CATO supplies Indocyanine Green Impurity 33 (CAS CATO-C4X-250333), a pharmacopoeial impurity reference standard (molecular formula C18H20NO4SNa, MW 369.41 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Indocyanine Green Impurity 33 (C18H20NO4SNa) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC18H20NO4S Na
Molecular Weight369.41 g/mol
Purity>90%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)9.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Nitrogen Atoms1
Sulfur Atoms1

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