Pretomanid Impurity 10 CAS CATO-C4X-260610
| CAS No. | CATO-C4X-260610 |
| Molecular Formula | C19H21BrF3N3O6 |
| Molecular Weight | 524.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pretomanid Impurity 10 (CAS CATO-C4X-260610) is a certified pharmaceutical impurity reference standard with the molecular formula C19H21BrF3N3O6 and a molecular weight of 524.29 g/mol.
The molecular framework of Pretomanid Impurity 10 (C19H21BrF3N3O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21BrF3N3O6 |
| Molecular Weight | 524.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
Related Pretomanid Standards
- Pretomanid Impurity 13 (CAS 2982828-82-8)
- Pretomanid Impurity 5 (CAS CATO-C4X-26065)
- Pretomanid Impurity 7 (CAS CATO-C4X-26067)
- Pretomanid Impurity 29 (CAS CATO-C4X-260629)
- Pretomanid Impurity 19 (CAS CATO-C4X-260619)
- Pretomanid Impurity 14 (CAS CATO-C4X-260614)
- Pretomanid Impurity 28 (CAS 2512206-85-6)
- Pretomanid Impurity 6 (CAS CATO-C4X-26066)
Recommended Standards
- Dimethoxybis(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)silane (CAS 1309602-60-5)
- Vilanterol Impurity 32 (CAS CATO-C4X-193532)
- [[(2S,3S,5R)-5-(6-aminopurin-9-yl)-3-azido-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (CAS 92562-94-2)
- (E)-N-(5-(Perfluoroethylidene)-4,4-bis(trifluoromethyl)-4,5-dihydrothiazol-2-yl)-4-(trifluoromethyl)benzothioamide (CAS 143811-19-2)
- Fosaprepitant Impurity 11 (CAS CATO-C4X-116811)
- Gadobutrol Impurity 185 (CAS CATO-C4X-2120185)
- Tetracaine Impurity 40 (CAS 63069-46-5)
- 5-Bromo-N-methylindoline-6-sulfonamide (CAS 113162-38-2)
- Bis(4-hydroxyphenyl)phenylphosphine oxide (CAS 795-43-7)
- N-Hydroxycyclopentanecarboximidamide (CAS 99623-12-8)
- 1,4-Benzenedicarboxylic acid, 1,4-dimethyl ester, polymer with 1,4-butanediol and .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) (CAS 9078-71-1)
- (S)-4-((R)-Sec-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole (CAS 1620588-66-0)
- 3-(Hydroxymethyl)tetrahydrofuran-3-ol (CAS 1232677-89-2)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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