Apalutamide Impurity 1 CAS CATO-C4X-27491
| CAS No. | CATO-C4X-27491 |
| Molecular Formula | C21H17F4N5O3S |
| Molecular Weight | 495.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Apalutamide Impurity 1 (CAS CATO-C4X-27491), a pharmacopoeial impurity reference standard (molecular formula C21H17F4N5O3S, MW 495.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Apalutamide Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 495.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Apalutamide Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17F4N5O3S |
| Molecular Weight | 495.45 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Apalutamide Standards
- Apalutamide Impurity 35 (CAS CATO-C4X-274935)
- Apalutamide Impurity 13 (CAS 2649802-40-2)
- Apalutamide Impurity 22 (CAS CATO-C4X-274922)
- Apalutamide Impurity 102 (CAS CATO-C4X-2749102)
- Apalutamide Impurity 112 (CAS CATO-C4X-2749112)
- Apalutamide Impurity 10 (CAS CATO-C4X-274910)
- Apalutamide Impurity 68 (CAS CATO-C4X-274968)
- Apalutamide Impurity 5 (CAS CATO-C4X-27495)
Recommended Standards
- 4-(4-Chlorophenyl)-1-{5-[(4-chlorophenyl)sulfanyl]-4-phenyl-1,3-thiazol-2-yl}-1H-pyrazol-5-amine (CAS 956205-96-2)
- (5R,6S)-benzyl 3-(dimethoxyphosphoryl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate (CAS 145761-32-6)
- Norfloxacin-acyl-β-glucuronide (CAS 1260617-45-5)
- Spironolactone EP Impurity B (CAS CATO-C4X-13452)
- Maribavir Impurity 35 (CAS CATO-C4X-300735)
- Upadacitinib Impurity 180 (CAS CATO-C4X-2405180)
- Perospirone Impurity 62 (CAS CATO-C4X-245862)
- 3-(1,3-Benzothiazol-2-yl-2,3-Difluoroacrylonitrile (CAS 26418-15-5)
- 2-{8-methylimidazo[1,2-a]pyridin-2-yl}acetonitrile (CAS 1216270-80-2)
- N-(9-((2R,4S,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide (CAS 75759-63-6)
- 21413-75-2 5H-Benzocyclohepten-5-one, 1-chloro-6,7,8,9-tetrahydro- (CAS 21413-75-2)
- Fmoc-Cys(Trt)-Cys(Psi(Dmp,H)pro)-OH (CAS 2022956-75-6)
- all-trans-Retinyl Oleate (CAS 631-88-9)
- Neuropeptide Y (porcine) trifluoroacetate salt (CAS 83589-17-7)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com