Spironolactone EP Impurity B CAS CATO-C4X-13452
| CAS No. | CATO-C4X-13452 |
| Molecular Formula | C24H31BrO4S |
| Molecular Weight | 495.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Spironolactone EP Impurity B.
CATO supplies Spironolactone EP Impurity B (CAS CATO-C4X-13452), a pharmacopoeial impurity reference standard (molecular formula C24H31BrO4S, MW 495.47 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Spironolactone EP Impurity B (C24H31BrO4S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Spironolactone EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H31BrO4S |
| Molecular Weight | 495.47 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Sulfur Atoms | 1 |
Related Spironolactone Standards
- Spironolactone EP Impurity D (CAS 3079028-52-4)
- Spironolactone EP Impurity G (CAS 880106-10-5)
- Spironolactone Impurity 20 (CAS CATO-C4X-134520)
- Spironolactone-d7(Major) (CAS CATO-CCAD302541)
- Spironolactone EP Impurity I (CAS CATO-C4X-13459)
- Spironolactone D3 (CAS 52-01-7 (Unlabeled))
- Spironolactone EP Impurity E (CAS 33784-05-3)
- Spironolactone (CAS 52-01-7)
Recommended Standards
- (5R,6S)-benzyl 3-(dimethoxyphosphoryl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate (CAS 145761-32-6)
- rel-(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazole (CAS 939981-35-8)
- Apalutamide Impurity 1 (CAS CATO-C4X-27491)
- Flomoxef Impurity 14 (CAS CATO-C4X-138214)
- Dotinurad Impurity 88 (CAS CATO-C4X-249488)
- Enrofloxacin Impurity 7 (CAS 93107-31-4)
- Deoxycholic acid Impurity 40 (CAS CATO-C4X-335940)
- 6-Amino-5-nitronicotinamide (CAS 159890-55-8)
- (2S,3S,4S)-Ethyl 3-(2-ethoxy-2-oxoethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylate (CAS 66163-47-1)
- 2-Methylthiazole-4-carbaldehyde (CAS 20949-84-2)
- (3-Fluoro-4-methoxyphenyl)(methyl)sulfane (CAS 66624-36-0)
- (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid (CAS 1228570-35-1)
- Potassium 2-hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate (CAS 65540-57-0)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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