Apalutamide impurity 93 CAS CATO-C4X-274993
| CAS No. | CATO-C4X-274993 |
| Molecular Formula | C14H10F3N3O3 |
| Molecular Weight | 325.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 325.24 g/mol gives Apalutamide impurity 93 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Apalutamide impurity 93 (CAS CATO-C4X-274993, C14H10F3N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Apalutamide impurity 93 (C14H10F3N3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apalutamide impurity 93 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10F3N3O3 |
| Molecular Weight | 325.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Apalutamide Standards
- Apalutamide impurity 86 (CAS CATO-C4X-274986)
- Apalutamide Impurity 79 (CAS CATO-C4X-274979)
- Apalutamide Impurity 94 (CAS CATO-C4X-274994)
- Apalutamide impurity 82 (CAS 2393949-01-2)
- Apalutamide impurity 92 (CAS CATO-C4X-274992)
- Apalutamide Impurity 113 (CAS CATO-C4X-2749113)
- Apalutamide Impurity 76 (CAS CATO-C4X-274976)
- Apalutamide Impurity 57 (CAS CATO-C4X-274957)
Recommended Standards
- U 4793e (CAS 67579-24-2)
- Niflumic acid impurity 2 (CAS CATO-C4X-30852)
- Methyl 4-nitro-3-(trifluoromethyl)-[1,1-biphenyl]-4-carboxylate (CAS 886361-47-3)
- 8-Benzyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene (CAS 1123661-15-3)
- Oseltamivir Impurity 28 (CAS 204254-94-4)
- Xanomeline Impurity 12 (CAS CATO-C4X-330112)
- Vitamin K1 Impurity 38 (CAS CATO-C4X-220738)
- 2-(3,3-Diethoxyprop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 608534-37-8)
- 3-Amino-3-(naphthalen-1-yl)propan-1-ol (CAS 683220-49-7)
- 3-Amino-2-[(2-chlorophenyl)methyl]propanoic acid hydrochloride (CAS 1258640-62-8)
- Bis((1-methyl-1h-pyrazol-4-yl)methyl)amine (CAS 1006446-08-7)
- 2,5-Dioxaspiro[3.4]octan-7-amine (CAS 2103779-12-8)
- 3-Bromoquinoline-8-carboxylic acid (CAS 1315366-78-9)
- Semaglutide impurity 269 (CAS CATO-C4X-2226269)
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