Apalutamide Impurity 94 CAS CATO-C4X-274994
| CAS No. | CATO-C4X-274994 |
| Molecular Formula | C16H21FN2O3 |
| Molecular Weight | 308.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Apalutamide Impurity 94 (CAS CATO-C4X-274994, C16H21FN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Apalutamide Impurity 94 (C16H21FN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apalutamide Impurity 94 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21FN2O3 |
| Molecular Weight | 308.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Apalutamide Standards
- Apalutamide impurity 92 (CAS CATO-C4X-274992)
- Apalutamide Impurity 79 (CAS CATO-C4X-274979)
- Apalutamide Impurity 76 (CAS CATO-C4X-274976)
- Apalutamide Impurity 57 (CAS CATO-C4X-274957)
- Apalutamide Impurity 78 (CAS CATO-C4X-274978)
- Apalutamide impurity 86 (CAS CATO-C4X-274986)
- Apalutamide impurity 93 (CAS CATO-C4X-274993)
- Apalutamide Impurity 26 (CAS CATO-C4X-274926)
Recommended Standards
- 697305-53-6 tert-Butyl 4-(4-fluoro-2-formylphenyl)piperazine-1-carboxylate DTXSID20470544 (CAS 697305-53-6)
- Fensulfothion (CAS 115-90-2)
- 501126-37-0 tert-Butyl 4-(2-fluoro-4-formylphenyl)piperazine-1-carboxylate DTXSID00609794 (CAS 501126-37-0)
- Ethyl 2-(1,5-dimethyl-1H-pyrazole-3-carboxamido)-4-methylthiazole-5-carboxylate (CAS 1013772-62-7)
- Mesalazine Impurity 26 (CAS 1689-82-3)
- Ilaprazole Impurity 177 (CAS CATO-C4X-1130177)
- Oseltamivir Impurity 44 (CAS 2413185-87-0)
- 6-Amino-5-fluoronicotinonitrile (CAS 1361058-62-9)
- 4-Bromo-2,3-difluoro-6-iodo-1-(trimethylsilyl)benzene (CAS 1807646-35-0)
- 5-(2-(Pentyloxy)benzylidene)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 617694-58-3)
- Tadalafil Impurity 51 (CAS CATO-C4X-108751)
- 1-Fluoro-4-isopropylbenzene (CAS 403-39-4)
- Benzyl Benzenesulfinate (CAS 29624-04-2)
- Liraglutide (CAS 204656-20-2)
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