Coclaurine Impurity 16 CAS CATO-C4X-275116
| CAS No. | CATO-C4X-275116 |
| Molecular Formula | C16H16N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Coclaurine Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Coclaurine Impurity 16 (CAS CATO-C4X-275116, C16H16N2O4CH4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Coclaurine Impurity 16 (C16H16N2O4CH4O) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 332.36 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H16N2O4 CH4O |
| Molecular Weight | 332.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Coclaurine Standards
- Coclaurine Impurity 112 (CAS 116331-72-7)
- Coclaurine Impurity 2 HCl (CAS 13233-00-6)
- Coclaurine Related Compound 1 (CAS 138644-99-2)
- (±)-Coclaurine HCl (CAS 17934-80-4)
- (R)-Coclaurine HCl (CAS 19894-19-0)
- Coclaurine Impurity 113 (CAS 2158198-78-6(TFA Salt))
- Coclaurine Impurity 111 (CAS 2158201-34-2(TFA Salt))
- (+)-Coclaurine (CAS 2196-60-3)
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