Clobazam Impurity 3 CAS CATO-C4X-27523
| CAS No. | CATO-C4X-27523 |
| Molecular Formula | C27H18Cl2N4O6 |
| Molecular Weight | 565.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clobazam Impurity 3 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Clobazam Impurity 3 (CAS CATO-C4X-27523), a pharmacopoeial impurity reference standard (molecular formula C27H18Cl2N4O6, MW 565.36 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clobazam Impurity 3 (C27H18Cl2N4O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 565.36 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clobazam Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H18Cl2N4O6 |
| Molecular Weight | 565.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clobazam Standards
- Clobazam EP Impurity D (CAS 2092997-47-0)
- Clobazam EP Impurity C (CAS 22316-16-1)
- Clobazam-d8 (CAS 1263274-30-1)
- Clobazam EP Impurity A (CAS 22316-55-8)
- Clobazam EP Impurity E (CAS 75524-13-9)
- Clobazam EP Impurity B (CAS 22316-24-1)
- Clobazam Impurity H (CAS 37385-92-5)
- Clobazam USP Related Compound G (CAS 75524-10-6)
Recommended Standards
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- C20:3 11-14-17 Eicosatrienoic Acid (CAS 2091-27-2)
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- 2-(3-Butyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid (CAS 329714-50-3)
- 1H-Benzotriazole-1-acetonitrile (CAS 111198-08-4)
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- tert-Butyl (4-(aminomethyl)bicyclo[2.2.1]heptan-1-yl)carbamate (CAS 1333384-66-9)
- 1-(2-Methylphenyl)-1H-imidazole-2-thiol (CAS 25372-14-9)
- Exenatide (CAS 141758-74-9（free base）)
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