Clobazam EP Impurity D CAS 2092997-47-0
| CAS No. | 2092997-47-0 |
| Molecular Formula | C18H17ClN2O2 |
| Molecular Weight | 328.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Clobazam EP Impurity D (CAS 2092997-47-0, C18H17ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clobazam EP Impurity D (C18H17ClN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 328.79 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17ClN2O2 |
| Molecular Weight | 328.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clobazam Standards
- Clobazam EP Impurity C (CAS 22316-16-1)
- Clobazam-d8 (CAS 1263274-30-1)
- Clobazam EP Impurity A (CAS 22316-55-8)
- Clobazam EP Impurity E (CAS 75524-13-9)
- Clobazam EP Impurity B (CAS 22316-24-1)
- Clobazam Impurity H (CAS 37385-92-5)
- Clobazam Impurity 3 (CAS CATO-C4X-27523)
- Clobazam USP Related Compound G (CAS 75524-10-6)
Recommended Standards
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- Landiolol Impurity 59 (CAS CATO-C4X-262159)
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- Trilostane Impurity 2 (CAS 2301065-59-6)
- CAS 1406-18-4 (CAS 1406-18-4)
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- Ethyl 2,4-difluoro-3-methoxybenzoate (CAS 817194-54-0)
- n-Isopropyl-3-sulfamoylbenzamide (CAS 1094316-66-1)
- 3-Methyl-4-heptanone (CAS 15726-15-5)
- Macitentan Impurity 15 (CAS 1642873-04-8)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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