Chlorzoxazone Impurity 3 CAS CATO-C4X-27773
| CAS No. | CATO-C4X-27773 |
| Molecular Formula | C15H8Cl2N2O4 |
| Molecular Weight | 351.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Chlorzoxazone Impurity 3 (C15H8Cl2N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Chlorzoxazone Impurity 3 (CAS CATO-C4X-27773) is a certified pharmaceutical impurity reference standard with the molecular formula C15H8Cl2N2O4 and a molecular weight of 351.14 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2N2O4 |
| Molecular Weight | 351.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorzoxazone Standards
- Chlorzoxazone Impurity 6 (CAS CATO-C4X-27776)
- Chlorzoxazone Impurity 5 (CAS CATO-C4X-27775)
- Chlorzoxazone Impurity 4 (CAS CATO-C4X-27774)
- Chlorzoxazone Impurity N1 (CAS 57718-28-2)
- Chlorzoxazone-2-<SUP>13</SUP>C-3-<SUP>15</SUP>N-Hydroxy-<SUP>18</SUP>O (CAS 1173023-63-6)
- Chlorzoxazone-d3 (CAS 1185173-60-7)
- Chlorzoxazone (CAS 95-25-0)
- Chlorzoxazone USP Related Compound A (CAS 95-85-2)
Recommended Standards
- 4-((5-Iodo-2,6-dimethylpyrimidin-4-yl)oxy)benzonitrile (CAS 860649-99-6)
- Benzyl 3-bromo-5-nitrophenylcarbamate (CAS 1020252-75-8)
- 3,4-Dihydro-2H-pyran-2-carboxylic acid (CAS 34201-01-9)
- 5-(Bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (CAS 1312023-72-5)
- Mycophenolate Impurity 20 (CAS 27979-57-3)
- Dasatinib Impurity 57 (CAS 2135905-86-9)
- Estradiol Impurity 6 (CAS 1423-97-8)
- ethyl 1,3-benzothiazole-6-carboxylate (CAS 19989-64-1)
- Vildagliptin Impurity 70 (CAS 79108-51-3)
- tert-Butyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate (CAS 335059-71-7)
- (1R,4R)-[4-((S)-2-Amino-3-methyl-butyrylamino)-cyclohexyl]-ethyl-carbamic acid benzyl ester (CAS 1354028-93-5)
- Tetramethyl 5,5,7-trimethyl-5,6-dihydrospiro[thiopyrano[2,3-c]quinoline-1,2'-[1,3]dithiole]-2,3,4',5'-tetracarboxylate (CAS 295347-16-9)
- Ethyl 3-phenylhexahydro-1H-pyrrolizine-1-carboxylate (CAS 1005095-99-7)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
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