Sacubitril impurity 52 CAS CATO-C4X-280952
| CAS No. | CATO-C4X-280952 |
| Molecular Formula | C25H31NO3 |
| Molecular Weight | 393.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Sacubitril impurity 52 (C25H31NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 393.52 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Sacubitril impurity 52 (CAS CATO-C4X-280952, C25H31NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sacubitril impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H31NO3 |
| Molecular Weight | 393.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril Impurity 30 (CAS CATO-C4X-280930)
- Sacubitril Impurity 26 (CAS CATO-C4X-280926)
- Sacubitril Impurity 8 (CAS CATO-C4X-28098)
- Sacubitril impurity 42 (CAS CATO-C4X-280942)
- Sacubitril Impurity 7 (CAS CATO-C4X-28097)
- Sacubitril Impurity C32 (CAS 1817838-91-7)
- Sacubitril impurity 45 (CAS 761373-05-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
Recommended Standards
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- Cyetpyrafen (CAS 1253429-01-4)
- Ledipasvir Impurity 58 (CAS CATO-C4X-331358)
- Buserelin Impurity 15 (CAS CATO-C4X-221215)
- Letermovir Impurity 22 (CAS CATO-C4X-291522)
- 2-(4-Chlorophenyl)-2-(2,2-dimethylmorpholino)ethan-1-amine (CAS 1156090-71-9)
- N-[2-(1H-Indol-3-yl)ethyl]-3-phenoxybenzamide (CAS 1023484-15-2)
- N-methyl-1-(2-methylpyrimidin-4-yl)methanamine (CAS 921091-02-3)
- 3-Methoxy-4-nitropicolinonitrile (CAS 348635-36-9)
- 6-(1H-imidazol-1-yl)pyridin-3-amine,2HCl (CAS 1431963-37-9)
- n-Methyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine (CAS 1178076-35-1)
- Vancomycin Hexapeptide (CAS 115236-65-2)
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