Alectinib Impurity 53 CAS CATO-C4X-283653
| CAS No. | CATO-C4X-283653 |
| Molecular Formula | C16H21IO3 |
| Molecular Weight | 388.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Alectinib Impurity 53 (CAS CATO-C4X-283653, C16H21IO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Alectinib Impurity 53 (C16H21IO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 388.24 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Alectinib Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21IO3 |
| Molecular Weight | 388.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
Related Alectinib Standards
- Alectinib impurity 28 (CAS 2412921-44-7)
- Alectinib Impurity 66 (CAS CATO-C4X-283666)
- Alectinib Impurity 40 (CAS CATO-C4X-283640)
- Alectinib Impurity 2 (CAS 1256579-06-2)
- Alectinib impurity 21 (CAS 1256584-91-4)
- Alectinib Impurity 54 (CAS CATO-C4X-283654)
- Alectinib Impurity 59 (CAS CATO-C4X-283659)
- Alectinib Impurity 75 (CAS CATO-C4X-283675)
Recommended Standards
- Tert-butyl (S)-4-iodo-2-isopropyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS 2366997-14-8)
- (S)-3-(4-(2-bromoethoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1333069-57-0)
- Tert-butyl (R)-4-iodo-2-isopropyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS 2366996-94-1)
- Propane-2,2-diylbis(4,1-phenylene) bis(dihydrogen phosphate) (CAS 181028-79-5)
- (Z)-Ceftizoxime Impurity 22 (CAS CATO-C4X-179322)
- Brexpiprazole impurity 116 (CAS CATO-C4X-1131116)
- Lurasidone Impurity 49 (CAS 59461-66-4)
- N-ethyl-1-methyl-4-nitro-1H-pyrazole-5-carboxamide (CAS 1245771-58-7)
- N-(4-Chlorophenethyl)-4-propoxyaniline (CAS 1040689-05-1)
- 2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(1,1,1,3,3,3-hexafluoropropan-2-ol) (CAS 2180-30-5)
- 3-(4-Chloro-2-methylphenoxy)propane-1-sulfonyl chloride (CAS 1496484-90-2)
- 1-(Benzofuran-3-yl)ethanone 3-Acetylbenzo[b]furan 66611-15-2 (CAS 66611-15-2)
- 2-(5-Methylpyridin-3-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (CAS 2416673-80-6)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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