Abrocitinib Impurity 37 CAS CATO-C4X-288437
| CAS No. | CATO-C4X-288437 |
| Molecular Formula | C11H14ClN5 |
| Molecular Weight | 251.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 251.72 g/mol gives Abrocitinib Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Abrocitinib Impurity 37 (CAS CATO-C4X-288437, C11H14ClN5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abrocitinib Impurity 37 (C11H14ClN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14ClN5 |
| Molecular Weight | 251.72 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Abrocitinib Standards
- Abrocitinib Impurity 19 (CAS CATO-C4X-288419)
- Abrocitinib Impurity 55 (CAS 252722-30-8)
- Abrocitinib Related Compound 3 (CAS 1622980-99-7)
- Abrocitinib Impurity 28 (CAS 2215069-40-0)
- Abrocitinib Impurity 57 (CAS 252853-75-1)
- Abrocitinib Impurity 29 (CAS 2204276-97-9)
- Abrocitinib Desmethyl Impurity 7 (CAS 2920890-22-6)
- Abrocitinib Impurity 46 (CAS CATO-C4X-288446)
Recommended Standards
- Cycloguanil HCl (CAS 516-21-2)
- 1-cyclopentanecarbonylazetidine-3-sulfonyl chloride (CAS 1461715-32-1)
- 7-chloro-3-cycloheptyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 65019-04-7)
- 4-Chloro-1-(3-(ethylsulfonyl)propyl)-1h-pyrazol-3-amine (CAS 1484798-62-0)
- Olaparib Impurity 30 (CAS 61260-15-9)
- Ezetimibe Impurity 118 (CAS CATO-C4X-1098118)
- Resmetirom impurity 93 (CAS CATO-C4X-291293)
- 1-Methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile (CAS 768-45-6)
- 1,4-Dimethyl-6-nitro-1,4-dihydroquinoxaline-2,3-dione (CAS 13784-21-9)
- rac-Pyrotinib, >98% (HPLC) (CAS 1246089-97-3)
- Ethyl 2-(5-bromobenzofuran-2-yl)acetate (CAS 408506-61-6)
- Methyl N-(4-bromophenyl)-N'-(4-methylbenzyl)carbamimidothioate (CAS 866157-58-6)
- 2-(6-Aminospiro[3.3]heptan-2-yl)propan-2-ol (CAS 2101630-83-3)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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