N-Nitroso Almonertinib impurity 4 CAS CATO-C4X-28924
| CAS No. | CATO-C4X-28924 |
| Molecular Formula | C11H15F3N4O |
| Molecular Weight | 276.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 276.26 g/mol gives N-Nitroso Almonertinib impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-Nitroso Almonertinib impurity 4 (CAS CATO-C4X-28924) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15F3N4O and a molecular weight of 276.26 g/mol.
The molecular framework of N-Nitroso Almonertinib impurity 4 (C11H15F3N4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15F3N4O |
| Molecular Weight | 276.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- N-Nitroso Ranolazine Impurity 14 (CAS CATO-C4X-102614)
- N-Nitroso Azelastine EP Impurity B (CAS CATO-C4X-139641)
- N-Nitroso Venlafaxine Impurity 52 (CAS CATO-C4X-143452)
- N-Nitroso Diphenhydramine EP Impurity A-d5 (CAS CATO-C4X-142419)
- N-Nitroso Salbutamol-d9 (CAS CATO-C4X-1176225)
- N-Nitroso Temazepam EP Impurity A (CAS 51145-18-7)
- N-Nitroso Bilastine impurity 129 (CAS CATO-C4X-2253129)
- N-Nitroso Linagliptin impurity 100 (CAS CATO-C4X-1101100)
Recommended Standards
- Etamsylate Impurity 2 (CAS CATO-C4X-28542)
- [5-(2-Furyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]acetic acid (CAS 1082403-21-1)
- Sitagliptin Impurity 60 (CAS CATO-C4X-114460)
- 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(thiophen-2-yl)urea (CAS 1211216-97-5)
- Cinitapride Impurity 33 (CAS CATO-C4X-290833)
- Lifitegrast Impurity 41 (CAS 851785-19-8)
- Emtricitabine Impurity 4 (CAS 145397-25-7)
- 2-(4-amino-3-methoxyphenyl)ethan-1-ol hydrochloride (CAS 1803603-83-9)
- Tert-butyl (2s)-2-({5-[(2,2-dimethoxyethyl)amino]-1h-1,2,3,4-tetrazol-1-yl}methyl)pyrrolidine-1-carboxylate (CAS 1212094-46-6)
- 2-(2-Methoxyphenyl)-1H-imidazo[4,5-b]pyridine (CAS 53929-99-0)
- (4aS,9bR)-Ethyl 6-bromo-5-(2-(methylamino)-2-oxoethyl)-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate (CAS 2098497-32-4)
- 5-Bromo-8-(bromomethyl)quinoxaline (CAS 1360599-45-6)
- 1-(tert-Butyl)-3,4-diethoxy-1H-pyrrole (CAS 220280-01-3)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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