Sitagliptin Impurity 60 CAS CATO-C4X-114460
| CAS No. | CATO-C4X-114460 |
| Molecular Formula | C11H15F3N4O |
| Molecular Weight | 276.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sitagliptin Impurity 60 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sitagliptin Impurity 60 (CAS CATO-C4X-114460) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15F3N4O and a molecular weight of 276.26 g/mol.
Structurally, Sitagliptin Impurity 60 (C11H15F3N4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 276.26 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15F3N4O |
| Molecular Weight | 276.26 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 72 (CAS CATO-C4X-114472)
- Sitagliptin Impurity 101 (CAS CATO-C4X-1144101)
- Sitagliptin Impurity 173 (CAS CATO-C4X-1144173)
- Sitagliptin Impurity 119 (CAS 2114328-77-5)
- Sitagliptin Impurity 169 (CAS CATO-C4X-1144169)
- Sitagliptin Impurity 170 (CAS CATO-C4X-1144170)
- Sitagliptin Impurity 168 (CAS CATO-C4X-1144168)
- Sitagliptin Impurity 171 (CAS CATO-C4X-1144171)
Recommended Standards
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