Vericiguat Impurity 40 TFA CAS CATO-C4X-289640
| CAS No. | CATO-C4X-289640 |
| Molecular Formula | C21H18F2N8O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Vericiguat Impurity 40 TFA is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Vericiguat Impurity 40 TFA (CAS CATO-C4X-289640) is a certified pharmaceutical impurity reference standard with the molecular formula C21H18F2N8O4C2HF3O2 and a molecular weight of 598.44 g/mol.
The molecular framework of Vericiguat Impurity 40 TFA (C21H18F2N8O4C2HF3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Vericiguat Impurity 40 TFA meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18F2N8O4 C2HF3O2 |
| Molecular Weight | 598.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat Impurity 100 (CAS 1011527-86-8)
- Vericiguat Impurity (CAS 117007-52-0)
- Vericiguat (CAS 1350653-20-1)
- Vericiguat Impurity 11 (CAS 1350653-29-0)
- Vericiguat Impurity 1 (CAS 1350653-30-3)
- Vericiguat Impurity 15 (CAS 1361232-73-6)
- Vericiguat Impurity 101 (CAS 1374344-58-7)
- Vericiguat Impurity N dihydrochloride (CAS 1426309-48-9)
Recommended Standards
- Clopidogrel Impurity 110 (CAS 2641358-57-6(free base))
- Ensifentrine impurity 34 (CAS CATO-C4X-335334)
- Cefminox Impurity 9 (CAS CATO-C4X-19269)
- Methyl 2-(2-bromo-3-cyano-6-formylphenyl)acetate (CAS 1805247-63-5)
- Dacarbazine EP Impurity C (CAS 1314929-56-0)
- Cis-6-butyl-4aH-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione (CAS 88332-14-3)
- 3-(4-Chlorophenyl)-9-(3-hydroxypropyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one (CAS 1010933-62-6)
- (3S)-1,4-oxazepane-3-carboxylic acid (CAS 1932083-95-8)
- 4-((tert-Butyldimethylsilyl)-oxy)-4-phenylbutan-1-ol (CAS 241818-03-1)
- Semaglutide-d8 Tetratrifluoroacetate (CAS CATO-C4X-222617)
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