Vericiguat Impurity 100 CAS 1011527-86-8
| CAS No. | 1011527-86-8 |
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vericiguat Impurity 100 (CAS 1011527-86-8) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17FN8O2 and a molecular weight of 408.39 g/mol.
Vericiguat Impurity 100 (C19H17FN8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat Impurity 3 (CAS 3052969-91-9)
- Vericiguat impurity 47 (CAS CATO-C4X-289647)
- Vericiguat impurity 53 (CAS CATO-C4X-289653)
- Vericiguat Impurity 62 (CAS CATO-C4X-289662)
- Vericiguat Impurity 67 (CAS 2755814-39-0)
- Vericiguat Impurity 77 (CAS CATO-C4X-289677)
- Vericiguat Impurity 17 (CAS 625115-49-3)
- Vericiguat Impurity 4 (CAS CATO-C4X-28964)
Recommended Standards
- Riociguat EP Impurity A (CAS 625115-52-8)
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
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- Dapagliflozin Impurity 114 (CAS CATO-C4X-1138114)
- Deferasirox Impurity 26 (CAS 1688656-83-8)
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- 2-(5-Chloro-2-(pentyloxy)phenyl)ethan-1-ol (CAS 1443340-36-0)
- N-Benzo[1,3]dioxol-5-ylmethyl-N,N-dimethyl-propane-1,3-diamine dihydrochloride (CAS 1185297-68-0)
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- 3-sec-Amylphenyl N-Methylcarbamate (CAS 2282-34-0)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
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